![](/__local/2/A1/90/83EFCC8C45E9113484B6B688150_6F681412_1CCE.jpg)
宋晓金,博士,研究员
中国科学院青岛生物能源与过程研究所
Email: songxj@qibebt.ac.cn
地址:山东省青岛市崂山区松岭路189号
邮编:266101
https://orcid.org/0000-0002-9094-3744
主要从事富油微生物的脂质合成代谢调控及高附加值脂质产品的发酵工程技术研究。通过分子生物学及多组学研究手段结合发酵工程技术研究微生物中脂质代谢调控机制及工业化转化。针对含有高附加值脂质化合物(如多不饱和脂肪酸、角鲨烯、萜类、脂质色素等)的新型富油微生物,在分子育种、发酵放大及下游产物分离纯化方面开展研究工作。主持国家自然科学基金、国家重点研发计划子课题、工信部绿色制造项目课题、中科院重点项目课题等20余项。发表论文40余篇,获得授权中国发明专利20项。作为主要完成人获得山东省科技进步二等奖1项,青岛市科技进步三等奖1项。
简历:
2023.02-今 中国科学院青岛生物能源与过程研究所/山东能源研究院 研究员
2013.12-2023.02中国科学院青岛生物能源与过程研究所副研究员
2010.06-2012.12中国科学院青岛生物能源与过程研究所助理研究员
2008.07-2010.06中国海洋大学生物学博士后
2003.09-2008.07中国海洋大学 海洋生物学专业博士
1999.09-2003.07中国海洋大学 生命科学专业学士
获奖及荣誉:
1.青海省“千人计划”-拔尖人才(2021年)
2.青岛市青年科技奖(2018)
3.山东省科学技术进步二等奖(2015, 3/9)
4.青岛市科学技术进步三等奖(2016, 4/8)
代表论著:
1.Wang, Z., Wang, S., Feng, Y., Wan, W., Zhang, H., Bai, X., Cui, Q.*,Song Xiaojin*. 2021. Obtaining high-purity docosahexaenoic acid oil in thraustochytridAurantiochytriumthrough a combined metabolic engineering strategy.J Agric Food Chem, 69(35), 10215-10222.(内封面文章)
2.Zhang, H., Cui, Q.,Song Xiaojin*. 2021. Research advances on arachidonic acid production by fermentation and genetic modification ofMortierella alpina.World J Microbiol Biotechnol, 37(1), 4.
3. Lu, X., Cui, Y., Chen, Y., Xiao, Y.,Song, Xiaojin, Gao, F., Xiang, Y., Hou, C., Wang, J., Gan, Q., Zheng, X., Lu, Y.*. 2021. Sustainable development of microalgal biotechnology in coastal zone for aquaculture and food.Sci Total Environ, 780, 146369.
4. Wang, S., Lan, C.Z., Wang, Z.J., Wan W.J., Zhang, H.D., Cui, Q.*,Song Xiaojin*, 2020. Optimizing eicosapentaenoic acid production by grafting a heterologous polyketide synthase pathway in the ThraustochytridAurantiochytrium. Journal of Agricultural and Food Chemistry, 68(40), 11253-11260.(内封面文章)
5. Lan, C., Wang, S., Zhang, H., Wang, Z., Wan, W., Liu, H., Hu, Y., Cui, Q.*,Song Xiaojin*. 2021. Cocktail biosynthesis of triacylglycerol by rational modulation of diacylglycerol acyltransferases in industrial oleaginousAurantiochytrium.Biotechnol Biofuels, 14(1), 246.
6. Wang, S., Wan, W., Wang, Z., Zhang, H., Liu, H., Arunakumara, K., Cui, Q.,Song Xiaojin*. 2021. A two-stage adaptive laboratory evolution strategy to enhance docosahexaenoic acid synthesis in oleaginous Thraustochytrid.Front Nutr, 8, 795491.
7. Wang, S., Lan, C.Z., Wang, Z.J., Wan W.J., Cui, Q.*,Song Xiaojin*, 2020. PUFA-synthase-specific PPTase enhanced the polyunsaturated fatty acids biosynthesis via the polyketide synthase pathway inAurantiochytrium.Biotechnology for Biofuels,13, 153.
8. Han, X.,Song Xiaojin, Li, F., Lu, Y. 2020. Improving lipid productivity by engineering a control-knob gene in the oleaginous microalgaNannochloropsis oceanica.Metab Eng Commun, 11, e00142.
9. Yang, J.,Song, Xiaojin, Wang, L., Cui, Q.*, 2020. Comprehensive Analysis of Metabolic Alterations inSchizochytriumsp. Strains with Different DHA Content.Journal of Chromatography B, 122193.
10. Cui, G. Z., Wang, Z. J., Hong, W., Liu, Y. J., Chen, Z. H., Cui, Q.*,Song, Xiaojin*, 2019. Enhancing tricarboxylate transportation-related NADPH generation to improve biodiesel production byAurantiochytrium.Algal Research, 40, 101505.
11. Zhang, H., Wang, Z., Feng, Y., Cui, Q.,Song, Xiaojin*, 2019. Phytohormones as stimulators to improve arachidonic acid biosynthesis inMortierella alpina.Enzyme and Microbial Technology, 131, 109381.
12. Wang, Y.,Song, Xiaojin, Feng, Y.; Cui, Q.*, 2019. Changes in peptidomes and Fischer ratios of corn-derived oligopeptides depending on enzyme hydrolysis approaches.Food Chemistry, 297, 124931.
13.Song, Xiaojin, Wang, J., Wang, Y., Feng, Y., Cui, Q., Lu, Y., 2018. Artificial creation ofChlorella pyrenoidosamutants for economic sustainable food production.Bioresource Technology,268, 340-345.
14. Zhang, H., Lu, D., Li, X., Feng, Y., Cui, Q.,Song, Xiaojin*, 2018. Heavy ion mutagenesis combined with triclosan screening provides a new strategy for improving the arachidonic acid yield inMortierella alpina.BMC Biotechnology, 18, 23.
15.Song, Xiaojin, Ma, Z., Tan, Y., Zhang, H., Cui Q.*, 2017. Wastewater recycling technology for fermentation in polyunsaturated fatty acid production,Bioresource Technology, 235, 79-86.
16. Ma, Z., Tian, M., Tan, Y., Cui, G., Feng, Y., Cui, Q.,Song, Xiaojin*. 2017. Response mechanism of the docosahexaenoic acid producerAurantiochytriumunder cold stress.Algal Research, 25, 191-199.
17. Zhang, H., Feng, Y., Cui, Q.*,Song Xiaojin*2017. Expression ofVitreoscillahemoglobin enhances production of arachidonic acid and lipids inMortierella alpina.BMC Biotechnology, 17(1), 68-77.
授权专利:
1.宋晓金;崔球;蓝传增;冯银刚,高温高盐环境下快速增殖的卤虫及其驯化方法,ZL 201910572410.6
2.宋晓金;刘欢;崔球;王森;张慧丹;万伟建;蓝传增,原位分析微生物菌落中角鲨烯含量的方法,ZL 202011006613.8
3.宋晓金;周晓峰;高旭光;朱玉军,微生物发酵生产PUFA的废水循环再利用的方法,ZL 202110577391.3
4.崔球;宋晓金;马增新;崔古贞;冯银刚,一种寇氏隐甲藻及其应用,ZL 201610547947.3
5.崔球;宋晓金;谭延振;王晓龙;冯银刚;李文利,一种高产角鲨烯的类酵母菌及其应用,ZL 201410829522.2
6.崔球;宋晓金;谭延振;冯银刚,富含n-3多不饱和脂肪酸的佐餐酱及其制备方法,ZL 201410632170.1
7.崔球;宋晓金;谭延振;冯银刚,一种裂殖壶菌及其应用,ZL 201410203041.0
8.崔球;宋晓金;王彦超;冯银刚;蓝传增,以微拟球藻渣为原料制备高附加值寡肽的方法,ZL 201810282276.1
9.崔球;谭延振;宋晓金;冯银刚,产多不饱和脂肪酸的高山被孢霉及其应用,ZL 201410222240.6
10.崔球;高莽;宋晓金;冯银刚,一种裂殖壶菌及利用其高密度发酵生产DHA油脂的方法,ZL 201210251850.X
11.崔球;邓煜;宋晓金;刘婷,富含均衡不饱和脂肪酸的橄榄油衍生物的制备及应用,ZL 201910519311.1
12.崔球;刘欢;宋晓金;王森;王卓君;蓝传增,原位分析微生物单菌落的激光电喷雾质谱装置,ZL 202011006611.9
13.崔球;刘冰;宋晓金;程琦;周晓峰;王彦超,改善鸡蛋蛋壳质量的饲料及养殖方法,ZL 201910366029.4
14.崔球;李悦明;宋晓金;徐建春;李霞;夏修峦;王道会,一种从海洋微藻发酵液中提取DHA的方法,ZL 201410060198.2
15.崔球;初欢欢;宋晓金;刘亚君;张慧丹,用于生产适合婴幼儿的DHA-ARA鸡蛋的营养强化剂及应用,ZL 201811282278.7
16.崔球;刘亚君;祁宽;宋晓金,采用木质纤维素培养微藻的方法,ZL 201810939294.2
17.崔球;刘亚君;刘世岳;宋晓金,采用木质纤维素制备DHA的方法,ZL 201810939182.7
18.冯银刚;兰君;谭延振;宋晓金;崔球,一种快速判定含油微生物细胞内多不饱和脂肪酸含量的方法,ZL 201410118153.6
承担科研项目情况:
1.国家自然科学基金面上项目-“脂滴蛋白维持裂殖壶菌脂质稳态的作用及调控机制的研究”(32270045),2023.01-2026.12。
2.国家重点研发计划“蓝色粮仓项目”-“水产品高质化生物加工新技术与产品开发”(2019YFD0901904),2019.11-2022.12。
3.中科院海洋大科学中心重点部署项目-“应用于海水绿色养殖新工艺创制的微藻功能性产品开发”(COMS2019J04),2019.11-2022.12。
4.山东省重点研发计划(医用食品专项)-“小球藻蛋白及其寡肽制备以及其在医用食品中的应用开发”(2019YYSP003),2019.08-2021.08。
5.山东省重点研发计划(公益类项目)-“功能脂质分子角鲨烯的微生物制备关键技术创新”(2019GHY112006),2019.01-2020.12。
6.青岛市科技成果集成熟化项目-“磷脂型DHA营养补充剂的制备工艺研究及产业化示范”(QIBEBT SHZX 201902),2019.01-2020.12。
7.工信部绿色制造系统集成项目-“二十二碳六烯酸生产绿色关键工艺开发与系统集成项目”(Z135060009002),2017.04-2019.12。
8.国土资源部海洋经济创新发展示范市项目-“热带海洋微藻高值化产品开发及产业链建设示范”(HHCL201803),2017.10-2020.10。
9.企业委托课题-“规模化异养培养系统开发”。
10.青岛市自主创新重大专项-“微拟球藻异养高效生产海洋功能制品EPA技术攻关及产业化质控体系项目”(16-7-1-11-zdzx-nsh),2016.05-2018.04。