东升，博士，副研究员
教育/工作经历
2005/09年-2009/06年，山东大学生命科学学院，本科/学士
2009/09年-2014/06，山东大学微生物技术国家重点实验室，硕博连读/博士
2014/07-2016/06，中国科学院青岛生物能源与过程研究所，代谢物组学团队，博士后
2016/06-2017/12，中国科学院青岛生物能源与过程研究所，代谢物组学团队，助理研究员
2018/01至今， 中国科学院青岛生物能源与过程研究所，代谢物组学团队，副研究员
发表论文
1. Sheng Dong, Ya-Jun Liu, Haixia Zhou, Yan Xiao, Jian Xu, Qiu Cui*, Xinquan Wang*, Yingang Feng* (2021) Structural insight into a GH1 β-glucosidase from the oleaginous microalga, Nannochloropsis oceanica. Int. J. Biol. Macromol. 170:196-206.
2. Xingzhe Yao†, Chao Chen†, Yefei Wang†, Sheng Dong, Ya-Jun Liu, Yifei Li, Zhenling Cui, Weibin Gong, Sarah Perrett, Lishan Yao, Raphael Lamed, Edward A. Bayer, Qiu Cui, Yingang Feng* (2020) Discovery and mechanism of a pH-dependent dual-binding-site switch in the interaction of a pair of protein modules. Sci. Adv. 6(43):eabd7182.
3. Fei Xiao, Sheng Dong, Yang Liu, Yingang Feng, Huayue Li, Cai-Hong Yun, Qiu Cui, Wenli Li* (2020) Structural basis of specificity for carboxyl-terminated acyl donors in a bacterial acyltransferase. J. Am. Chem. Soc. 142(37):16031-16038.
4. Zhen Wei, Chao Chen, Ya-Jun Liu, Sheng Dong, Jie Li, Kuan Qi, Shiyue Liu, Xiaoke Ding, Lizett Ortiz de Ora, Iván Muñoz-Gutiérrez, Yifei Li, Hongwei Yao, Raphael Lamed, Edward A. Bayer, Qiu Cui, Yingang Feng* (2019) Alternative σI/anti-σI factors represent a unique form of bacterial σ/anti-σ complex. Nucleic Acids Res. 47(11):5988-5997.
5. Sheng Dong, Xi Liu, Gu-Zhen Cui, Qiu Cui*, Xinquan Wang*, Yingang Feng* (2018) Structural insight into the catalytic mechanism of a cis-epoxysuccinate hydrolase producing enantiomerically pure D(-)-tartaric acid. Chem. Commun. 54(61):8482-8485.
6. Ya-Jun Liu†*, Shiyue Liu†, Sheng Dong, Renmin Li, Yingang Feng*, and Qiu Cui* (2018) Determination of the native features of the exoglucanase Cel48S from Clostridium thermocellum. Biotechnol. Biofuels 11, 6.
7. Dong-Dong Meng†, Xi Liu†, Sheng Dong†, Ye-Fei Wang, Xiao-Qing Ma, Haixia Zhou, Xinquan Wang, Li-Shan Yao, Yingang Feng*, and Fu-Li Li* (2017) Structural insights into the substrate specificity of a glycoside hydrolase family 5 lichenase from Caldicellulosiruptor sp. F32. Biochem. J. 474(20), 3373-3389.(†Co-first authors)
8. Lei Du†, Sheng Dong†, Xingwang Zhang, Chengying Jiang, Jingfei Chen, Lishan Yao, Xiao Wang, Xiaobo Wan, Xi Liu, Xinquan Wang, Shaohua Huang, Qiu Cui, Yingang Feng*, Shuang-Jiang Liu*, and Shengying Li* (2017) Selective oxidation of aliphatic C-H bonds in alkylphenols by a chemomimetic biocatalytic system. Proc. Natl. Acad. Sci. USA 114(26):E5129-E5137. (†Co-first authors)
9. Chen XL, Dong S, Xu F, Dong F, Li PY, Zhang XY, Zhou BC, Zhang YZ, Xie BB.(2016) Characterization of a New Cold-Adapted and Salt-Activated Polysaccharide Lyase Family 7 Alginate Lyase from Pseudoalteromonas sp. SM0524. Front. Microbiol. 7:1120.
10. Yang JY, Wang P, Li CY, Dong S, Song XY, Zhang XY, Xie BB, Zhou BC, Zhang YZ, Chen XL. (2016) Characterization of a New M13 Metallopeptidase from Deep-Sea Shewanella sp. E525-6 and Mechanistic Insight into Its Catalysis. Front. Microbiol. 6:1498.
11. Dong S. †, Wei TD†, Chen XL, Li CY, Wang P, Xie BB, Qin QL, Zhang XY, Pang XH, Zhou BC, Zhang YZ. (2014) Molecular insight into the role of the N-terminal extension in the maturation, substrate recognition, and catalysis of a bacterial alginate lyase from polysaccharide lyase family 18. J. Biol. Chem. 289(43):29558-29569. (†Co-first authors)
12. Guo, B., P. Y. Li, Y. S. Yue, H. L. Zhao, S. Dong, X. Y. Song, C. Y. Sun, W. X. Zhang, X. L. Chen, X. Y. Zhang, B. C. Zhou & Y. Z. Zhang, (2013) Gene cloning, expression and characterization of a novel xylanase from the marine bacterium, Glaciecola mesophila KMM241. Mar Drugs 11: 1173-1187.
13. Dong, S., J. Yang, X. Y. Zhang, M. Shi, X. Y. Song, X. L. Chen & Y. Z. Zhang, (2012) Cultivable alginate lyase-excreting bacteria associated with the Arctic brown alga Laminaria. Mar Drugs 10: 2481-2491.
14. Li, J. W., S. Dong, J. Song, C. B. Li, X. L. Chen, B. B. Xie & Y. Z. Zhang, (2011) Purification and characterization of a bifunctional alginate lyase from Pseudoalteromonas sp. SM0524. Mar Drugs 9: 109-123.
15. Zhang, W. X., B. B. Xie, X. L. Chen, S. Dong, X. Y. Zhang, B. C. Zhou & Y. Z. Zhang, (2010) Domains III and I-2{alpha}, at the entrance of the binding cleft, play an important role in cold adaptation of the periplasmic dipeptide-binding protein (DppA) from the deep-sea psychrophilic bacterium Pseudoalteromonas sp. strain SM9913. Appl Environ Microbiol 76: 4354-4361.
