科研团队 科研团队

最小化 最大化

        代谢物组学团队目前有工作人员20名,在读研究生7名,其中博士研究生4名,硕士研究生3名。已毕业博士研究生11名,硕士研究生14名(7名本所和7名联合培养)。

工作人员

   崔球 博士,研究员,团队负责人

   丁筱珂 硕士,团队秘书

   冯银刚 博士,研究员

   肖艳 博士,副研究员

   宋晓金 博士,副研究员

   刘亚君 博士,副研究员

   东升 博士,副研究员

   陈超 博士,助理研究员

   王森 博士,助理研究员

   张慧丹 博士,博士后

   刘纪阳 学士,技术员

   封雪梅 学士,技术员

   周晓峰 硕士,工程师

   杨杰 博士,博士后

   万伟建 硕士,科研助理

   马豪,技术员

   李华坤,技术员

   刘欢 博士,助理研究员

   刘博洋 硕士,科研助理

   田晓荣 硕士,科研助理

硕博在读

桃李天下

刘亚君 刘亚君

最小化 最大化

刘亚君,博士,副研究员

于中国科学院微生物研究所攻读博士学位期间获德意志学术交流中心与中国科学院博士生联合培养项目(DAAD-CAS Joint Program)奖学金,赴德学习,2011年取得博士学位,并获得中国科学院优秀毕业生称号。2011年加入中国科学院青岛生物能源与过程研究所代谢物组学团队,主要研究领域为围绕农林废弃物等低值生物质的生物降解利用的应用研究,以产纤维小体高效纤维素降解菌热纤梭菌为对象,主要开展纤维小体结构与功能研究,纤维素降解梭菌的遗传改造以及木质纤维素糖化工艺的开发等研究。近年来承担国家级、省部级、地市级及企业合作项目6项,作为第一作者和通讯作者在Biotechnol Biofuels, ISME J等国际杂志上发表SCI论文20余篇,作为主要参与人编著3项国内外著作,作为主要发明人申请专利3项。

教育经历

2001年-2005年,中国海洋大学,海洋生命学院,本科/学士

2005年-2011年,中国科学院微生物研究所,硕博连读/博士,导师刘双江研究员

工作经历

2011年-2013年,中国科学院青岛生物能源与过程研究所,助理研究员

2014年至今         中国科学院青岛生物能源与过程研究所,副研究员

主要代表性论文(第一作者及通讯作者):

1.        Shiyue Liu†, Ya-Jun Liu†, Yingang Feng, Bin Li and Qiu Cui* (2019) Construction of consolidated bio-saccharification biocatalyst and process optimization for highly efficient lignocellulose solubilization. Biotechnol. Biofuels 12:35.

2.        Ya-Jun Liu, Kuan Qi, Jie Zhang, Chao Chen, Qiu Cui*, Yingang Feng* (2018) Firmicutes-enriched IS1447 represents a group of IS3-family insertion sequences exhibiting unique +1 transcriptional slippage. Biotechnol. Biofuels 11:300.

3.        Renmin Li, Yingang Feng, Shiyue Liu, Kuan Qi, Qiu Cui*, Ya-Jun Liu* (2018) Inducing effects of cellulosic hydrolysate components of lignocellulose on cellulosome synthesis in Clostridium thermocellum. Microbial Biotechnol. 11(5):905-916.

4.        Liu YJ†*, Liu, S.,†, Dong S., Li R., Feng Y.*, and Cui Q.* (2018) Determination of the native features of the exoglucanase Cel48S from Clostridium thermocellum. Biotechnol. Biofuels 11, 6.

5.        Zhang, J., Liu S., Li R., Hong W., Xiao Y., Feng Y., Cui Q. and Liu, YJ.. "Efficient whole-cell-catalyzing cellulose saccharification using engineered Clostridium thermocellum." Biotechnol. Biofuels10(1):124.2017

6.        Liu, YJ, Song X, Li Y, Xuan J, Cui Q, Wang J, Feng Y. Low stability of the reduced state of Mycobacterium tuberculosis NrdH redoxin. FEBS Lett. 590(3): 387-395. 2016

7.        Zhang J, Liu YJ*, Cui GZ, Cui Q*. A novel arabinose-inducible genetic operation system developed for Clostridium cellulolyticum. Biotechnol. Biofuels8(1):36. 2015

8.        Liu YJ, Zhang J, Cui GZ, Cui Q*. Current progress of targetron technology: Development, improvement and application in metabolic engineering. Biotechnol J. 10(6):855-865. 2015

9.        Liu, YJand Cui, Q. Metabolic Engineering of Thermophiles for Biofuel Production. Thermophilic Microorganisms. F.-L. Li, Caister Academic Press. 2015

10.    Hong W, Zhang J, Feng Y, Mohr G, Lambowitz AM, Cui GZ, Liu YJ*, Cui Q*. The contribution of cellulosomal scaffoldins to cellulose hydrolysis by Clostridium thermocellum analyzed by using thermotargetrons. Biotechnol. Biofuels7:80. 2014

11.    Cui GZ, Zhang J, Hong W, Xu C, Feng Y, Cui Q*, Liu YJ*. Improvement of ClosTron for successive gene disruption in Clostridium cellulolyticum using a pyrF-based screening system. Appl. Microbiol. Biotechnol. 98(1): 313-323. 2014

12.    刘亚君,崔古贞, 洪伟, 张杰, 崔球*. 典型产纤维小体梭菌的遗传改造及其在纤维素乙醇中的应用研究进展. 生物加工过程. 12(1):55-62.2014

13.    Mohr G, Hong W, Zhang J, Cui GZ, Yang Y, Cui Q, Liu YJ*, Lambowitz AM*. A targetron system for gene targeting in thermophiles and its application in Clostridium thermocellum. PLoS One 8(7):e69032.2013

14.    Liu YJ,Liu SJ, Drake HL, Horn MA*. Consumers of 4-chloro-2-methylphenoxyacetic acid from agricultural soil and drilosphere harbor cadA, r/sdpA, and tfdA-like gene encoding oxygenases. FEMS Microbiol. Ecol. 86(1):114-29. 2013

15.    Cui GZ, Hong W, Zhang J, Li WL, Feng Y, Liu YJ*, Cui Q*. Targeted gene engineering in Clostridium cellulolyticum H10 without methylation. J. Microbiol. Methods 89(3):201-8. 2012

16.    Qiang Tang†, Zhiping Zhao†, Yajun Liu†, Nanxi Wang, Baojun Wang, Yanan Wang, Ningyi Zhou, Shuangjiang Liu* (2012). Augmentation of tribenuron methyl removal from polluted soil with Bacillus sp. strain BS2 and indigenous earthworms. J. Environ. Sci. 24(8), 1492-1497. (†Co-first authors)

17.    Ya-Jun Liu, Shuang-Jiang Liu, Harold L. Drake, and Marcus A. Horn*. (2011) Alphaproteobacteria Dominate Active 2-Methyl-4-Chloro Phenoxyacetic Acid (MCPA) Degrading Bacteria in Agricultural Soil and Drilosphere. Environ. Microbiol. 13(4), 991-1009.

18.    Ya-Jun Liu,Adrienne Zaprasis, Shuang-Jiang Liu, Harold L. Drake, and Marcus A. Horn* (2011). The Earthworm Aporrectodea caliginosa Stimulates Abundance and Activity of Phenoxalkanoic Acid Herbicide Degraders. ISME J. 5(3), 473-485.

19.    Adrienne Zaprasis†, Ya-Jun Liu†, Shuang-Jiang Liu, Harold L. Drake, and Marcus A. Horn* (2010) Abundance of Novel and Diverse tfdA-Like Genes, Encoding Putative Phenoxyalkanoic Acid Herbicide-Degrading Dioxygenases, in Soil. Appl. Environ. Microbiol. 76:119-128. (†Co-first authors)

20.    Pan-Pan Li†,Ya-Jun Liu†, and Shuang-Jiang Liu* (2009) Genetic and biochemical identification of the chorismate mutase from Corynebacterium glutamicum. Microbiology 155(10), 3382-3391. (†Co-first authors)

21.    Ya-Jun Liu†, Pan-Pan Li†, Ke-Xin Zhao, Bao-Jun Wang, Cheng-Ying Jiang, Harold L. Drake, and Shuang-Jiang Liu* (2008). Corynebacterium glutamicum contains 3-deoxy-D-arabino-heptulosonate 7-phosphate synthases that display novel biochemical features. Appl. Environ. Microbiol. 74(17), 5497-5503. (†Co-first authors)